Speak with a Scientist Epidermal Growth Factor
Epidermal growth factor (EGF) is a small protein and powerful mitogen. EGF promotes cell growth and differentiation, is essential in embryogenesis, and is important in wound healing. It is produced by many normal cell types and is made in large amounts by some tumors.
Swiss-Prot Accession Number: P01133
Therapy Indications
PublicationsEvaluation of Serum Biomarkers Associated with Radiographic Progression in Methotrexate-naive Rheumatoid Arthritis Patients Treated with Methotrexate or Golimumab (2013) Wagner C, Chen D, Fan H, Hsia EC, Mack M, Emery P, Fleischmann RM J Rheumatol. 2013 Mar 1. [Epub ahead of print]
Sweet Bing Cherries Lower Circulating Concentrations of Markers for Chronic Inflammatory Diseases in Healthy Humans (2013) Kelley DS, Adkins Y, Reddy A, Woodhouse LR, Mackey BE, Erickson KL J Nutr. 2013 Jan 23. [Epub ahead of print]
Electroconvulsive therapy exerts mainly acute molecular changes in serum of major depressive disorder patients (2012) Stelzhammer V, Guest PC, Rothermundt M, Sondermann C, Michael N, Schwarz E, Rahmoune H, Bahn S Eur Neuropsychopharmacol. 2012 Nov 22. pii: S0924-977X(12)00303-3
Peripheral profiling analysis for bipolar disorder reveals markers associated with reduced cell survival (2011) Herberth M, Koethe D, Levin Y, Schwarz E, Krzyszton ND, Schoeffmann S, Ruh H, Rahmoune H, Kranaster L, Schoenborn T, Leweke MF, Guest PC, Bahn S Proteomics 11: 94-105.
Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV (2011) Casrouge A, Decalf J, Ahloulay M, Lababidi C, Mansour H, Vallet-Pichard A, Mallet V, Mottez E, Mapes J, Fontanet A, Pol S, Albert ML J Clin Invest. 121: 308-317.
Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections. (2010) Domenici E, Willé DR, Tozzi F, Prokopenko I, Miller S, McKeown A, Brittain C, Rujescu D, Giegling I, Turck CW, Holsboer F, Bullmore ET, Middleton L, Merlo-Pich E, Alexander RC, Muglia P PLoS ONE 5: e9166.
Human cytokine response to Texas crotaline envenomation before and after antivenom administration. (2010) Crocker P, Zad O, Milling T, Maxson T, King B, Whorton E Am J Emerg Med. 28: 871-9.
Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease (2010) Chen-Plotkin AS, Hu WT, Siderowf A, Weintraub D, Goldmann Gross R, Hurtig HI, Xie SX, Arnold SE, Grossman M, Clark CM, Shaw LM, McCluskey L, Elman L, Van Deerlin VM, Lee VM, Soares H, Trojanowski JQ Ann Neurol. Nov 29. [Epub ahead of print]
The Link Between Heightened Thrombogenicity and Inflammation: Pre-Procedure Characterization of the Patient at High Risk for Recurrent Events After Stenting. (2009) Gurbel PA, Bliden KP, Kreutz RP, Dichiara J, Antonino MJ, Tantry US Platelets 20: 97-104.
Identifying early markers of Alzheimer’s disease using quantitative multiplex proteomic immunoassay panels (2009) Soares HD, Chen Y, Sabbagh M, Roher A, Schrijvers E, Breteler M Ann N Y Acad Sci. 1180 :56-67.
The multiplex bead array approach to identifying serum biomarkers associated with breast cancer (2009) Kim BK, Lee JW, Park PJ, Shin YS, Lee WY, Lee KA, Ye S, Hyun H, Kang KN, Yeo D, Kim Y, Ohn SY, Noh DY, Kim CW Breast Cancer Res. 11: R22.
Regression of Human Pancreatic Tumor Xenografts in Mice After a Single Systemic Injection of Recombinant Vaccinia Virus GLV-1h68. (2009) Yu YA, Galanis C, Woo Y, Chen N, Zhang Q, Fong Y, Szalay AA Mol Cancer Ther 8: 141-151.
Bead-based Multiplexed Immunoassays to Identify New Biomarkers in Maternal Serum to Improve First Trimester Down Syndrome Screening. (2009) Koster MP, Pennings JL, Imholz S, Rodenburg W, Visser GH, de Vries A, Schielen PC Prenat Diagn 29: 857-862.
Effects of the incubation in vitro with sorbents on serum proteomic pattern and cytokine concentration in cancer patients during chemotherapy–preliminary results. (2006) Piccolomini F, LouWratten M, Sereni L, Balestreri E, Donadio E, Felicioli A, Felicioli R, Donadio C Biomed Pharmacother 60: 463-467.