Matrix Metalloproteinase-3

Matrix Metalloproteinase-3 (MMP-3), also termed Stromelysin-1, can degrade numerous extracellular matrix (ECM) substrates such as fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. MMP-3 activates procollagenase and MMP-9. It can also release cell surface molecules such as heparin-binding EGF-like growth factor and TNF-alpha and inactivate several serine proteinase inhibitors.

Swiss-Prot Accession Number: P08254

 
Product Associations
Human CytokineMAP B v 1.0
Human InflammationMAP® v 1.0
TruCulture MAP v 1.1
HumanMAP® v 1.6
Human DiscoveryMAP® 175+ v1.0
Human CardiovascularMAP® v 1.0
HumanMAP® 2.0
 
 
Therapy Indications
Autoimmune Disease and Arthritis
Cancer
Cardiac and Vascular Markers/Disease
Cytokines/Chemokines
Inflammation and Immune Response
 
Publications
Markers of inflammation and bone remodelling associated with improvement in clinical response measures in psoriatic arthritis patients treated with golimumab (2012) Wagner CL, Visvanathan S, Elashoff M, McInnes IB, Mease PJ, Krueger GG, Murphy FT, Papp K, Gomez-Reino JJ, Mack M, Beutler A, Gladman D, Kavanaugh A Ann Rheum Dis. 2012 Sep 12. [Epub ahead of print]
Proteins involved in extracellular matrix dynamics are associated with respiratory syncytial virus disease severity (2012) Schuurhof A, Bont L, Hodemaekers HM, de Klerk A, de Groot H, Hofland RW, van de Pol AC, Kimpen JL, Janssen R Eur Respir J. 2012 Jun;39(6):1475-81
2D-electrophoresis and multiplex immunoassay proteomic analysis of different body fluids and cellular components reveal known and novel markers for extended fasting (2011) Bouwman FG, de Roos B, Rubio-Aliaga I, Crosley LK, Duthie SJ, Mayer C, Horgan G, Polley AC, Heim C, Coort SL, Evelo CT, Mulholland F, Johnson IT, Elliott RM, Daniel H, Mariman EC BMC Med Genomics. Mar 25;4(1):24. [Epub ahead of print]
Association of serum markers with improvement in clinical response measures after treatment with golimumab in patients with active rheumatoid arthritis despite receiving methotrexate: results from the GO-FORWARD study (2010) Visvanathan S, Rahman MU, Keystone E, Genovese M, Klareskog L, Hsia E, Mack M, Buchanan J, Elashoff M, Wagner C Arthritis Res Ther. 12:R211
Matrix metalloproteinases during and outside of migraine attacks without aura. (2009) Ashina M, Tvedskov JF, Lipka K, Bilello J, Penkowa M, Olesen J Cephalalgia 30: 303-310.
Biomarker analysis by fluorokine multianalyte profiling distinguishes patients requiring intervention from patients with long-term quiescent coronary artery disease: a potential approach to identify atherosclerotic disease progression. (2008) Gurbel PA, Kreutz RP, Bliden KP, DiChiara J, Tantry US Am Heart J 155: 56-61.
Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma. (2008) Ding Y, Boguslawski EA, Berghuis BD, Young JJ, Zhang Z, Hardy K, Furge K, Kort E, Frankel AE, Hay RV, Resau JH, Duesbery NS Mol Cancer Ther 7: 648-658.
Effects of the incubation in vitro with sorbents on serum proteomic pattern and cytokine concentration in cancer patients during chemotherapy–preliminary results. (2006) Piccolomini F, LouWratten M, Sereni L, Balestreri E, Donadio E, Felicioli A, Felicioli R, Donadio C Biomed Pharmacother 60: 463-467.