Human SMA-MAP v. 1.0

SMA-MAP is a quantitative service measuring 27 plasma proteins associated with motor function and other outcome measures for Spinal Muscular Atrophy (SMA). SMA is a devastating neuromuscular disease that is the leading genetic cause of death in infants and toddlers, and causes progressive and debilitating weakness in older children and adults. These 27 markers have been evaluated in multiple SMA patient collections and several of these proteins are expressed in tissues that include the central nervous system and/or muscle. SMA-MAP provides a comprehensive and efficient platform for biomarker validation and may help accelerate the development of new treatments for SMA.

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Sample Volume Requirements
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Analytes included in this MAP are subject to change.
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1. AXL Receptor Tyrosine Kinase 2. Apolipoprotein B
3. C-Reactive Protein 4. Cadherin-13
5. Cartilage Oligomeric Matrix Protein 6. Cathepsin D
7. Complement Factor H – Related Protein 1 8. Complement component C1q receptor
9. Dipeptidyl peptidase IV 10. Endoglin
11. Fetuin-A 12. Fibulin-1C
13. Human Epidermal Growth Factor Receptor 2 14. Insulin-like Growth Factor Binding Protein 6
15. Leptin 16. Lumican
17. Monocyte Chemotactic Protein 1 18. Myoglobin
19. Osteopontin 20. Peptidase D
21. Placenta Growth Factor 22. Serum Amyloid P-Component
23. Tenascin-X 24. Tetranectin
25. Thrombospondin-4 26. YKL-40
27. Insulin-like Growth Factor I

Intended for Research Use Only.